ISOLATION AND ANTIMICROBIAL ACTIVITY OF SARRACENIN FROM ROOT BARK OF STRYCHNOS SPINOSA.

T. A. Tor-Anyiin, J. O. Igoli, J. V. Anyam, J. N. Anyam

Abstract


A known iridoid, Sarracenin, was isolated from the root bark of Strychnos spinosa using Vacuum Liquid Chromatography and gel filteration. Its structure was elucidated by 1D and 2D-NMR experiments(DEPTq135, H, H-COSY, HMBC, HSQC and NOESY), and comparison with reported data.  . This is the first time it has been isolated from this species. The compound showed significant antimicrobial activities against Staphylococcus aureus, Streptococcus pyogenes, Shigella dysenteriae, Klebsiella pneumonia, Candida albicans Candida tropicalis, Candida thrusei, and Candida stellatoidea,respectively.


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Chemical Society of Nigeria