Antifungal activities of Zerovalent Cobalt and Nickel nanocomposites Integrated with Crosslinked Chitosan-Humic acid against some Candida species

C.A. Akinremi, N. N. Omos, S. Adewuyi, M. A. Idowu, S. A. Amolegbe, A. O. Atayese


Zerovalent Cobalt and Nickel nanocomposites with crosslinked Chitosan-Humic acid were synthesized. Humic acid was used for intramolecular cross-linking of the chitosan linear chains to increase the active sites on the chitosan biopolymer which was further used as stabilizer to synthesize zerovalent metal nanoparticles by the reduction of metal chlorides with sodium borohydride. Characterization of the products was carried out using Infrared spectrophotometer, Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM) and Powder X-Ray Diffractometer (PXRD). Chitosan, humic acid and the nanocomposites were investigated for antifungal activity against four Candida species (C. albicans, C. glabrata, C. tropicalis and C. parapsilosis). Significant antifungal activity was observed with the highest against Candida albicans.

Keywords: Chitosan, Humic acid, Antifungal property, Metal nanoparticle

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