SPECTROSCOPIC AND ANTIBACTERIAL STUDIES OF SOME NITRO-SUBSTITUTED N-(BENZOYLCARBAMOTHIOYL) AMINO ACIDS: THE CRYSTAL STRUCTURE OF N-(3-NITRO-BENZOYLCARBAMOTHIOYL)-GLYCINE

M. Fayomi Omotola, R. Sha’Ato, A. Wuana, O. Igoli John, Vashen Moodley, E. Van Zy Werner

Abstract


A series of nitro-substituted N-(benzoylcarbamothioyl)-amino acids (1-4) was synthesized by condensing 3- or 4-nitro-benzoyl isothiocyanate with amino acids (glycine and histidine). These compounds were characterized by HNMR, CNMR, FTIR, and MS. N-(3-nitro- benzoylcarbamothioyl)-glycine was also characterized by single crystal X-ray diffraction study. The compound crystallizes in triclinic space group P-1 with Z=2, a = 3.9354(4) Å, b= 12.6015(14) Å, c = 16.8149(16) Å, α = 71.451(5)°, β = 88.933(3)°, γ = 82.720(3)°. The preliminary antibacterial tests of the compounds gave good activity.

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Chemical Society of Nigeria