SYNTHESIS, CHARACTERIZATION AND APPLICATION OF CARBOXYMETHYL Sweitenia mycrophylla GUM. A POTENTIAL EXCIPIENT

O. Adeyanju, E. A. Ewaoche, J. Plavec

Abstract


Sweitenia mycrophylla gum was chemically modified via carboxymethylation and utilized as a binder in drug formulation. The product was characterized by X-ray diffraction (XRD), Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (NMR) spectroscopy. Physicochemical characteristics of the native and carboxymethyl gum such as viscosity, solubility and swelling power were also determined. The modified gum with the degree of substitution 0.24 had higher physicochemical properties than the native gum. The carboxymethyl gum granules pocessed better flow properties with hausner ratio of 1.09 to 1.29 and carr’s index of 8.9 to 22%. Tablet prepared with 4-8%w/w gum had hardness  5kg while tablets prepared with 6-8%w/w  binders had friability of less than 1% comparable to that prepared with 4% w/w gelatin BP and gum Arabic. The disinstegration time of the tablets was less than 15minutes. The tablets had fast dissolution in 45 minutes. The result showed that chemical modification via carboxymethylation may improve the viscosity, solubility and swelling power of gum which may result in higher efficacy for effective utilization in pharmaceutical formulations. 

Key words: Carboxymethyl groups, Sweitenia mycrophylla, gum, excipient, FTIR,NMR, 


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Chemical Society of Nigeria