A COMPARATIVE STUDY ON THE ANTIMICROBIAL ACTIVITY OF MIXED LIGAND COMPLEXES OF SCHIFF BASES AND AMINO ACIDS WITH DIVALENT COPPER.

E. T. Omotade, A. P. Oviawe, S. E. Ofeke

Abstract


The mixed ligand Cu(II) complexes involving Schiff bases (L) and amino acids (AH):4-benzylimino-2,3-dimethyl-1-phenylpyrazal-5-one(L1) and L-lysine (Lys); 4-N-dimethylaminobenzylimino-2,3-dimethyl-1-phenylpyrazal-5-one(L2) and L-asparagine (Asn); benzyliminothiosemicarbarzide (L3) and L-phenylalanine (Phe); and the three Schiff bases stated above, each with D-phenylalanine (D-Phe),have been synthesized and characterized by analytical and spectroscopic methods. All the complexes were screened for their in-vitro antimicrobial activity against bacteria viz. E. coli, P. aeroginosa, S. aureus, B. subtilis and fungi viz. C. albicans and A. niger; by agar-well diffusion method. The minimum inhibitory concentrations (MICs) of the mixed ligand complexes were determined by agar plate serial dilution method. The Cu(II) complexes possessed great antimicrobial activity with CuL1Lys being the greatest antimicrobial. The MICs of the complexes was 0.25-0.50mg/mL. The mixed ligand complexes should find use in pharmaceutical formulations.

Keywords: Antimicrobial, comparative, Schiff bases, amino acids, mixed ligand, complexes


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