Synthesis of 1, 1-bis(2-carbamoylguanidino)furan-2- ylmethane

K. J. Orie, R. I. Ngochindo, O. J. Abayeh


This study reports the synthesis of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane,in a 2 step synthesis. The first step involves the coupling of furfural with urea to obtain 1-((2- carbamoylguanidino)(furan-2-ylmethyl)urea, which was subsequently refluxed with more urea in ethanol for 1 hour to afford the product. Both intermediate and product were characterized by GC- MS, IR, 1H-NMR, 13C-NMR, 1H-1H COSY, HSQC, and DEPT. The product obtained from the study is a novel compound with possible outlets in the pharmaceutical and chemical industries.

Keywords: Furfural, Urea, 1-((2-carbamoylguanidino)(furan-2-ylmethyl)urea, 1,1-bis(2- Carbamoylguanidino)furan-2-ylmethane

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