ANTIPLASMODIAL ACTIVITY OF COCHLOSPERMUM PLANCHONI ROOT AGAINST Plasmodium berghei

M.M. Kareem, F.O. Bamiro, A.K. Akinlabi

Abstract


There is paucity of information on the efficacy of many plants used for antimalarial. This study investigated the antiplasmodial activity of Cochlospermum planchoni (CP) used in antimalaria herbal preparations. The roots of CP collected were air-dried and 1000 g of the sample was extracted with water. In vivo antimalaria study was carried out using Rane’s test. Six groups (n = 6) of Swiss albino mice (22-29 g) were inoculated with 1.0×107 Plasmodium berghei parasitised erythrocytes and administered  with 100, 200, 400  mg/kg each of the aqueous root extract, chloroquine (10  mg/kg), artesunate (4  mg/kg) and water (0.3 mL) following standard methods (AOAC 1990). At day 3 post-treatment, the aqueous root extract exhibited 73.79, 75.40 and 81.17% mean suppression for 100, 200, 400 mg/kg/day while chloroquine and artesunate showed 91.97 and 30.48% mean suppression respectively on the same day. This results showed that aqueous root extract of C. planchoni has good antiplasmodial activity and compared favourably with the standard drug –chloroquine  

Keywords: Antiplasmodial; Cochlospermum planchoni; antimalariaplants; Plasmodium berghei.


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Chemical Society of Nigeria