A DAMMARANE TRITERPENOID ESTER FROM COMBRETUM GLUTINOSUM PERR. EX. DC., STEM BARK

N. F. Amako, J.O. Amupitan

Abstract


Petroleum ether extract of Combretum glutinosum stem bark was chromatographed on silica gel column using petroleum ether: ethylacetate (19:1) followed by a gradient of ethylacetate up to 100%, and finally washed with methanol. Similar fractions were pooled together on the basis of their RF values and further purified by preparative thin layer chromatography using petroleum ether: ethylacetate (19:1). This afforded a triterpenoid with dammarane carbon skeleton. 1HNMR and 13CNMR analysis enabled its identification as 3 b- acetoxydammar-21(22)-ene.  Other compounds isolated were 2,4-di-tert-butylphenol and beta amyrin, their  identity were also ascertained using GC/MS comparison with authentic samples.

 Keywords: Combretum glutinosum perr. ex. dc., 3b- acetoxydammar-21(22)-ene,  2,4-di-tert-butyl phenol, and beta amyrin.


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Chemical Society of Nigeria