Novel Compounds from Homalium letestui (Flacourtiaceae)

B. N. Ita, R. I. Ngochindo


Homalium letestui is used traditionally in Nigeria as a medicinal plant. N-(2-Isobutyl-5-isopropyl-8,9-dimethyldec-6-enyl)propionamide, I (ringonamide), and 4-(cyclohex-3-enyl)-3-hydroxy-6-isopropyl-8-methylnonanoic acid, II (banitoic acid) have been isolated from the methanol extracts of Homalium letestui. Their structures were elucidated by spectrometric techniques including Electrospray Ionisation Time-of–Flight Mass Spectroscopy (ESI-ToF-MS), UV, IR, 1H, 13C, and 2D NMR experiments. The isolated compounds exhibited moderate antimicrobial and antioxidant activities.

Keywords: Homalium letestui, fractionation, structure determination, bioassay.

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Chemical Society of Nigeria