SYNTHESIS, CHARACTERISATION AND ANTIBACTERIAL ACTIVITY OF 2 - (PHENYL SULFONYL) AMINO PYRIDINE.

Abstract

The synthesis of 2-(phenylsulfonyl)amino pyridine is reported. This was achieved by sulfonylation of 2-aminopyridine using benzenesulfonyl chloride in alkaline medium while employing water as solvent. The structure of the synthesized compound was elucidated using the Ultra Violet, Fourier-transform infrared spectroscopy(FTIR) and Nuclear magnetic resonance (NMR) spectra data obtained. The antibacterial activity of the synthesized compound was tested on Staphylococcus aureus, Escherichia coli and Salmonella typhi using agar well diffusion method to establish the inhibition zone diameter for these microbes. The result of inhibition zone diameter obtained showed that the synthesized compound inhibited the growth of the test organisms and so have potential as an antimicrobial agent