BIOLOGICAL ACTIVITY STUDIES OF GUANIDINE-PHOSPHONATE COMPLEXES OF IRON, COBALT AND ZINC

Abstract

This research work focused on biological activity studies of guanidine-phosphonate complexes of iron, cobalt and zinc for growth inhibition against Staphyloccoccus aureus. Staphyloccoccus aureus infected blood was treated with the guanidine-phosphonate complexes and their activities were examined through haematological and enzymatic analyses. Sterile water was used as negative control. The analyses results on packed cell volume, haemoglobin, white blood cell, platelet, neutrophils, lymphocyte, aspartateaminotransferase and alanineaminotransferase were interpreted statistically. Guanidinophosphonateben zothiazole compounds exhibited strongest activity followed by guanidinobenzothiazole compounds. The effectiveness trend was followed by guanidinophosphonatebenzimidazole compounds which performed better than the guanidinobenzimidazole compounds. The compounds therefore indicated that guanidinophosphonatebenzothiazole compounds gave highest antimicrobial property. This was followed by guanidinobenzothiazole compounds which were found to be higher than guanidinephosphonatebenzimi dazole compounds while the least antimicrobial activity was recorded for guanidinobenzimidazole compounds