GUANIDINE DERIVATIVES OF CO(II), NI(II), CU(II) COMPLEXES AND HEPATITIS ACTIVITIES STUDIES
DOI:
https://doi.org/10.46602/jcsn.v49i6.1020Abstract
This study determined hepatitis B and hepatitis C effectiveness of guanidine derivative, cobalt(II), nickel(II) and copper(II) complexes using rats as test animal. Histopathological analysis was carried out. The derivatives demonstrated effectiveness at 2 mg kg-1 (w/w) for 5 ml kg-1 (v/w) concentration. Phosphonate compounds of benzothiazole demonstrated highest treatment, guanidine compouds of benzothiazole.were found to be next effective. The effectiveness trend was followed by phosphonate compounds of benzimidazole which performed better than the benzimidazole compounds of the guanidine. The derivatives compete favourably with the vaccine contre hepatitis recombinant standard which gave similar results of the analysis. The treatment properties of the derivatives therefore demonstrated that benzimidazole compounds of the guanidine < phosphonate compounds of benzimidazole < guanidine compounds of benzothiazole < phosphonate compounds of benzothiazoleDownloads
Published
2024-12-16
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Aremu, J. A. ., Durosinmi, L. M. ., Ojo, I. A. O. ., Oluyemi, E. A. ., Akinlabi, A. K. ., & Oluduro, A. O. . (2024). GUANIDINE DERIVATIVES OF CO(II), NI(II), CU(II) COMPLEXES AND HEPATITIS ACTIVITIES STUDIES . Journal of Chemical Society of Nigeria, 49(6). https://doi.org/10.46602/jcsn.v49i6.1020
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Copyright (c) 2024 J. A. Aremu, L. M. Durosinmi, I. A. O. Ojo, E. A. Oluyemi, A. K. Akinlabi, A. O. Oluduro

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