GUANIDINE DERIVATIVES OF CO(II), NI(II), CU(II) COMPLEXES AND HEPATITIS ACTIVITIES STUDIES

Authors

  • J. A. Aremu
  • L. M. Durosinmi
  • I. A. O. Ojo
  • E. A. Oluyemi
  • A. K. Akinlabi
  • A. O. Oluduro

DOI:

https://doi.org/10.46602/jcsn.v49i6.1020

Abstract

This study determined hepatitis B and hepatitis C effectiveness of guanidine derivative, cobalt(II), nickel(II) and copper(II) complexes using rats as test animal. Histopathological analysis was carried out. The derivatives demonstrated effectiveness at 2 mg kg-1 (w/w) for 5 ml kg-1 (v/w) concentration. Phosphonate compounds of benzothiazole demonstrated highest treatment, guanidine compouds of benzothiazole.were found to be next effective. The effectiveness trend was followed by phosphonate compounds of benzimidazole which performed better than the benzimidazole compounds of the guanidine. The derivatives compete favourably with the vaccine contre hepatitis recombinant standard which gave similar results of the analysis. The treatment properties of the derivatives therefore demonstrated that benzimidazole compounds of the guanidine < phosphonate compounds of benzimidazole < guanidine compounds of benzothiazole < phosphonate compounds of benzothiazole

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Published

2024-12-16

How to Cite

Aremu, J. A. ., Durosinmi, L. M. ., Ojo, I. A. O. ., Oluyemi, E. A. ., Akinlabi, A. K. ., & Oluduro, A. O. . (2024). GUANIDINE DERIVATIVES OF CO(II), NI(II), CU(II) COMPLEXES AND HEPATITIS ACTIVITIES STUDIES . Journal of Chemical Society of Nigeria, 49(6). https://doi.org/10.46602/jcsn.v49i6.1020

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