PHYTOCHEMICAL SCREENING AND ANTI-CANCER STUDY OF ETHYLACETATE EXTRACTS OF TWO AFRICAN Tapinanthus SPECIES

Authors

  • A. A. Azeez
  • A. Bhatnagar
  • S. H. Makana
  • C. C. Mandal
  • V. Kumar
  • S. A. Aboaba

DOI:

https://doi.org/10.46602/jcsn.v50i1.1044

Abstract

Cancer- a multifaceted disease- is one of the leading causes of mortality in the world and breast cancer is currently a significant global health issue. Cancer cells in general have developed resistance to most of the existing therapies. Tapinanthus species have been reported for treatment cancer by traditional healers in Africa. For this study, ethylacetate extracts of Tapianthus buntigii growing on Citrus paradise and Tapinanthus dodoneifolius hosted by Parkia biglobosa were screened for phytochemical constituents and anticancer potentials against MDA-MB-231, an a aggressive cancer cell line using MTT assay. The result of phytochemical screening revealed presence of steroids, saponins and cardiac glycosides but absence of tannins, terpenoids, alkaloids, and flavonoids. The extracts showed comparable anticancer activities against the cell line. From the results of this study, it is concluded that the Tapinanthus species could be reservoirs for potent anticancer drugs or lead compounds.

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Published

2025-02-23

How to Cite

Azeez, A. A. ., Bhatnagar, A. ., Makana, S. H. ., Mandal, C. C. ., Kumar, V. ., & Aboaba, S. A. . (2025). PHYTOCHEMICAL SCREENING AND ANTI-CANCER STUDY OF ETHYLACETATE EXTRACTS OF TWO AFRICAN Tapinanthus SPECIES . Journal of Chemical Society of Nigeria, 50(1). https://doi.org/10.46602/jcsn.v50i1.1044

Issue

Vol. 50 No. 1 (2025): J. Chem. Soc. Nigeria

Section

Articles

License

Copyright (c) 2025 A. A. Azeez, A. Bhatnagar, S. H. Makana, C. C. Mandal, V. Kumar, S. A. Aboaba

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution (CC-BY) 4.0 License that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal.

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