ANTIMICROBIAL ACTIVITY OF TRITERPENOIDS FROM Brachystegia eurycoma
DOI:
https://doi.org/10.46602/jcsn.v50i1.1047Abstract
Antibiotic resistance poses a significant global health threat, necessitating the search for novel antimicrobial agents. Natural products offer promising alternatives due to their structural diversity and evolutionary refinement. The antibacterial activity of crude extracts of the stem bark of Brachystegia eurycoma against Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant Escherichia coli (VRE) was investigated. The stem bark was extracted using hexane, ethyl acetate, and methanol, then column chromatography led to the isolation of friedelan-3-one, 2-hydroxy lupeol, and prunetin. The ethyl acetate extract exhibited the highest activity with a minimum inhibitory concentration of 45.0 µg/mL for MRSA and 10.0 µg/mL for VRE. The study highlights the potential of B. eurycoma as a source of bioactive compounds for antibiotic drug development.Downloads
Published
2025-02-23
How to Cite
Ahile, S. K. ., Ichoron, N. ., Anyam, . J. ., Tor-Anyiin, T. A. ., & Igoli, J. O. . (2025). ANTIMICROBIAL ACTIVITY OF TRITERPENOIDS FROM Brachystegia eurycoma . Journal of Chemical Society of Nigeria, 50(1). https://doi.org/10.46602/jcsn.v50i1.1047
Issue
Section
Articles
License
Copyright (c) 2025 S. K. Ahile, N. Ichoron, J.V. Anyam, T. A. Tor-Anyiin, J. O. Igoli
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution (CC-BY) 4.0 License that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal.
