NMR CHARACTERIZATION AND APPLICATION OF OXIDIZED Sweitenia mycrophylla GUM. A POTENTIAL EXCIPIENT

Abstract

Oxidized S.mycrophylla gum was prepared, characterized using NMR spectroscopy and evaluated for its binding capacity in paracetamol tablet formulation. All the granules possessed good flow properties with Hausner ratio of 1.00 - 1.20 and Carr's index of 9.0 – 13.0%. Tablets  prepared with 4-8% w/w oxidized gum had hardness   4kg while tablets prepared with 6-8% w/w oxidized gum had friability of   less than 1% comparable to that prepared with 4% w/w gelatin Bp which was used as a standard binder. The disintegration time of the tablets was <15minutes and increased with increase in oxidized gum concentration. The tablets had fast dissolution in aqueous media' with > 94% drug dissolution in 45minutes, the study shows that oxidized gum can be used as a binder in conventional release tablet formulation.Key Words:Carboxyl group, Sweitenia mycrophylla gum, excipient, NMR.