Preliminary Investigation on Probable Drug-Beverages Interactions Involving Carbonated Soft Drinks with Ascorbic Acid and Ciprofloxacin

Abstract

Food-drug interactions have interested researchers for quite some time, and new research continues to shed more light on this subject. The aim of this study is to investigate the possibility of functional group changes in the structure of Ciprofloxacin and Ascorbic acid, as well as in the structure of chemically active constituents of some selected Carbonated Soft Drinks when interactions occur between them. Varied doses of Ciprofloxacin and Ascorbic acid were dissolved in commercially available beverages: Pepsi, Maltina, Fanta and Bottled water using a constant volume of 50 mL.  The pH and temperature were monitored throughout the dissolution period. The resulting mixture was analyzed using an FTIR spectrometer. Comparison of the FTIR spectra obtained showed formation of some new functional groups as well as suppression of some of the functional groups present in Ciprofloxacin and Ascorbic acid indicative of probable interaction between the tested drugs and the beverages used. Key words: Food-drug, Ciprofloxacin, Ascorbic Acid, Carbonated Soft Drinks, Organic Functional Group.