SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND BIOLOGICAL STUDIES OF 2-{[(2-HYDROXY-5-METHOXYPHENYL) METHYLIDENE] AMINO} NICOTINIC ACID AND ITS MANGANESE (II) COMPLEXES

Abstract

Manganese(II) complexes of 2-{[(2-hydroxy-5-nitrophenyl) methylidene]amino} nicotinic acid derived from o-phenylenediamine and 5- nitrosalicaldehyde were synthesized and characterized by elemental analysis, using IR, 1HNMR, 13CNMR, and GCMS. They were screened against known disease causative microbes to establish their potentials as antimicrobial agents compared with national standards drugs. Results showed that, a Schiff base exhibited antimicrobial action against all the bacteria and most of the fungi with exception of Candidas. albicans isolate, which exhibited zero diameter zone of inhibition. It was also found that the synthesized Schiff base exhibited two digits purity range, implying that it was relatively stable. The metal complex was found to be more susceptible in overall biological activity due to the structural stability, showing their potency in pharmacognocy.