FUNCTIONALIZED CHITOSAN-MAGNETITE NANOPARTICLES FOR IN-VITRO CONTROLLED DRUG DELIVERY

Authors

  • O.B. Akinsipo Department of Chemistry, College of Natural Sciences, Federal University of Agriculture,
  • W.B. Ayinde
  • S.O. Alayande
  • B.J. Ogunbayo
  • F.O. Oladoyinbo
  • E.O. Dare

Abstract

Chitosan was employed for the coating of synthesized magnetic nanoparticles (MNPs) to achieve a targetable in-vitro delivery of drug. Sol-gel approach was employed in the synthesis of MNPs and a facile single step method was used in the in-situ coating of MNPs with Chitosan. Chitosan, MNPs and CS-MNPS were characterized using SEM, XRD and FT-IR. Magnetic release and delivery process were evaluated in an in-vitro magnetic release system using a phosphate buffer medium of pH 7.4. The different results obtained confirmed a nanospherical MNPs with an average particle size of 38 nm. Chitosan layer on the surface of MNPs and the controlled magnetic release test proved a sustainable release of MNPs from CS after 12hours. The result proved that chitosan can serve as a biocompatible and non-toxic material for site specific in-vitro controlled delivery of magnetite drug. Keywords: Magnetite, Chitosan, Drug Delivery, Nanoparticles. 

Downloads

Published

2017-02-14

How to Cite

Akinsipo, O., Ayinde, W., Alayande, S., Ogunbayo, B., Oladoyinbo, F., & Dare, E. (2017). FUNCTIONALIZED CHITOSAN-MAGNETITE NANOPARTICLES FOR IN-VITRO CONTROLLED DRUG DELIVERY. Journal of Chemical Society of Nigeria, 41(2). Retrieved from https://journals.chemsociety.org.ng/index.php/jcsn/article/view/61

Issue

Vol. 41 No. 2 (2016)

Section

Articles

License

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution (CC-BY) 4.0 License that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal.