FUNCTIONALIZED CHITOSAN-MAGNETITE NANOPARTICLES FOR IN-VITRO CONTROLLED DRUG DELIVERY
AbstractChitosan was employed for the coating of synthesized magnetic nanoparticles (MNPs) to achieve a targetable in-vitro delivery of drug. Sol-gel approach was employed in the synthesis of MNPs and a facile single step method was used in the in-situ coating of MNPs with Chitosan. Chitosan, MNPs and CS-MNPS were characterized using SEM, XRD and FT-IR. Magnetic release and delivery process were evaluated in an in-vitro magnetic release system using a phosphate buffer medium of pH 7.4. The different results obtained confirmed a nanospherical MNPs with an average particle size of 38 nm. Chitosan layer on the surface of MNPs and the controlled magnetic release test proved a sustainable release of MNPs from CS after 12hours. The result proved that chitosan can serve as a biocompatible and non-toxic material for site specific in-vitro controlled delivery of magnetite drug.Â Keywords: Magnetite, Chitosan, Drug Delivery, Nanoparticles.Â
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