ANALYSIS OF THE BIOLOGICAL PROPERTY OF SOME SYNTHESIZED ORGANOTIN (IV) COMPLEXES OF HEXANEDIOIC ACID

Abstract

Organotin compounds find a wide range of technological, agricultural, and industrial applications. In this research three organotin (IV) complexes were synthesized of the type Ph3SnL, Ph2SnL2, and Bu2SnL2 with the ligand L; (HOOC(CH2)4COOK). The ligand was prepared by reacting hexanedioic acid with KOH while complexes were synthesized by reacting L with Ph3SnOH, Ph2SnO, and Bu2SnO separately in methanol-propanol solvents. These compounds were tested for antimicrobial activity against two Gram-positive bacteria: Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant enterococci, three Gram-negative Bacteria: Salmonella typhi, Pseudomonas aeruginosa and Acetobacter sp and seven fungi strains: Aspergillus nigre, Aspergillus flavus, Monascus ruber, Candida albicans, Microsporum canis, Rhizopus sp, and Fomitopsis pinicola. Three standard drugs: ciprofloxacin, fulcin, and ketoconazole were used at the concentration of 10 μg/mL as control drugs. Results showed that compounds synthesized in general exhibited significant antimicrobial activity higher than the ligand with inhibition zones ranging from 20 – 33 mm at the minimum inhibition concentration (MIC) and minimum bactericidal and fungicidal concentrations (MBC/MFC) range from 12.50 – 50 μg/mL and 50 – 200 μg/mL, respectively. The order for the antibacterial and antifungal activity in this study was Ph3SnL Ph2SnL2 > Bu2SnL2> L. Organotin moieties play a vital role in deciding the antimicrobial activity of an organotin compound; this is true in this work.