SYNTHESIS CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF SOME STRONTIUM-HYDRAZONE COMPLEXES

Abstract

Hydrazones and their coordinated compounds were prepared for antimicrobial activi ties investigation while hydrazides were prepared from their esters. The hydrazides were reacted with benzaldehyde to produce benzoylhydrazone, m-nitrobenzoylhyd razone, p-nitrobezoylhydrazone, 3,5 dinitrobenzoylhydrazone, p-aminobenzoylhyd razone and m-aminobenzoylhydrazone in white, off white, light-yellow, deep-yellow and light-brown colours. Complexes were synthesized from strontium chloride and the hydrazones which produced off-white, grey, light-brown and dark-brown complexes. The ligand-metal compounds were analyzed through complexometric titration while characterization of all the samples were based on spectra data. Metal to hydrazone stoichiometry of 1:0.5 to 1:3 were proposed for the complexes. Relevant assignments were made in the hydrazones and complexes for possible points of coordination. Physicochemical properties of the ligands and their coordinated compounds were determined. Antimicrobial Properties of the compounds demonstrated good performance on Streptococcus faecalis, Clostridium sporosenes, Baccillus anthracis, Pseudomonas fluorescenes, Saccharomyces cerevisiae and Hansenula anomala. Nanohybrid study of the samples is recommended for future studies on the antimicrobial activities.