EFFECT OF AMLODIPINE ON MONOSODIUM GLUTAMATE-INDUCED CARDIAC OXIDATIVE STRESS IN RATS

Authors

  • A. C. C. Egbuonu
  • P. O. Alaebo
  • O. C. Atasie
  • J. C. Obike
  • C. L. Anoliefo
  • G. F. Iroerunachi
  • E. C. Lewechukwu
  • I. C. Egwu
  • D. S. Okeohia
  • F. C. Obinna
  • U. B. Okeke
  • H. Nwokenna
  • F. N. Ndukamma
  • M. N. Nwaiwe
  • I. G. Oti

DOI:

https://doi.org/10.46602/jcsn.v48i2.864

Abstract

Monosodium glutamate, MSG, induces oxidative stress which underlies many ailments including inflammation and heart dysfunctions. Amlodipine, AML, an anti-hypertensive could result to unknown effects on the cardiac oxidative function when co-taken with MSG. This study evaluated the effect of AML against experimental MSG-induced cardiac oxidative stress. Thus, rats orally and for 14 consecutive days received MSG (8000 mg/Kg/day). Cardiac oxidative stress bio-indicators: malondialdehyde, MDA, nitric oxide, NOX, glutathione peroxidase, GPX, superoxide dismutase, SOD, catalase, CAT, albumin, ALB, total protein, TP, magnesium, Mg, and zinc, Zn were determined. MSG significantly (p < 0.05) increased MDA and Zn but decreased others without altering NOX content compared to control rats in consistency with induction of cardiac oxidative stress in the rats. AML dose-dependently mitigated these MSG-induced oxidative effects. Thus, AML can protect against MSG-induced cardiac oxidative stress in the rats. Keywords: Monosodium glutamate, Amlodipine, Oxidative stress, Heart, Nitric oxide

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Published

2023-04-21

How to Cite

Egbuonu, A. C. C. ., Alaebo, P. O. ., Atasie, . O. C. ., Obike, J. C. ., Anoliefo, C. L. ., Iroerunachi, G. F. ., Lewechukwu, E. C. ., Egwu, I. C. ., Okeohia, D. S. ., Obinna, F. C. ., Okeke, U. B. ., Nwokenna, H. ., Ndukamma, F. N. ., Nwaiwe, M. N. ., & Oti, I. G. . (2023). EFFECT OF AMLODIPINE ON MONOSODIUM GLUTAMATE-INDUCED CARDIAC OXIDATIVE STRESS IN RATS . Journal of Chemical Society of Nigeria, 48(2). https://doi.org/10.46602/jcsn.v48i2.864

Issue

Vol. 48 No. 2 (2023): J. Chem. Soc. Nigeria

Section

Articles