FTIR SPECTROSCOPIC ANALYSIS AND EVALUATION OF ANTIMALARIAL POTENTIAL OF ETHANOL STEM-BARK EXTRACT OF Sarcocephalus latifolius (Smith Bruce) PLANT.

Authors

  • I. Yinusa
  • H. D Kabiru
  • K. B Ahmad

DOI:

https://doi.org/10.46602/jcsn.v48i6.938

Abstract

Malaria is a parasitic disease that causes serious human health problems worldwide, especially in tropical Africa. This work was carried out to investigate the phytochemical component of the ethanol stem-bark extract of Sarcocephalus latifolius for possible phytochemicals that could be present and analyze for possible functional groups present for inference and carry out the antiplasmodial activity of the extract at different doses in mice infected with Plasmodium berghei. From the result, the phytochemical screening of the extract revealed the presence of carbohydrates, anthraquinones, cardiac glycoside, saponins, steroids, triterpenes, tannins, flavonoids, and alkaloids, while glycosides were absent. Some prominent peaks observed from the FTIR analysis are the aromatic ring at 1651.12 (C-C=C asymmetric stretch), Phenols and alcohol at 3356.25 (O-H stretch), Carboxylic acid at 2924.18 (O-H stretch), Ketone at 1651.12 (C=O stretch), Aldehyde at 1697.41 (C-H stretch of C=O), Primary amine at 3417.98 (N-H stretch), Secondary amine at 1450.52 (N-H stretch), Amides at 3417.98 (N-H stretch). The extract shows significant (p<0.05 dose dependent) chemosuppression of the parasite. The result from this study shows that a maximum of 91.7% chemosuppression of P.berghei in mice is reported after administration of the ethanol stem bark extract at a level of 400 mg kg-1 b.wt. while the acute toxicity (LD50) of the extract was estimated to be 3162 mg kg-1 b. wt. This extract has been shown to possess antiplasmodial potency.

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Published

2024-01-03

How to Cite

Yinusa, I. ., Kabiru, . H. D., & Ahmad, K. B. . (2024). FTIR SPECTROSCOPIC ANALYSIS AND EVALUATION OF ANTIMALARIAL POTENTIAL OF ETHANOL STEM-BARK EXTRACT OF Sarcocephalus latifolius (Smith Bruce) PLANT . Journal of Chemical Society of Nigeria, 48(6). https://doi.org/10.46602/jcsn.v48i6.938