Microwave-Assisted Solvent-Free Arylation of Amino acids with Halogenobenzenes

Authors

  • Modupeola A. Sowole
  • Adesola B. Adebisi
  • Idris A. Olasupo
  • Josephat U. Izunobi
  • Oluwole B. Familoni

Abstract

The solventless microwave-assisted arylation and heteroarylation of different aliphatic and cyclic amino acids 2a–e were carried out on activated, substituted o-nitrohalogenobenzenes 1a–h and 2-chloro-3-nitropyridine 1i, in the presence of potassium carbonate and potassium fluoride for 0.5 h at 70 W, to give substituted N-(o-nitrophenyl)amino-2-carboxylic acid 3–16 and N-(m-nitropyridyl)amino-2-carboxylic acid 17–18 adducts in yields ranging from 5–98% .  Keywords: amino acids, arylation, halogenobenzenes, microwave synthesis 

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Published

2018-07-09

How to Cite

A. Sowole, M., B. Adebisi, A., A. Olasupo, I., U. Izunobi, J., & B. Familoni, O. (2018). Microwave-Assisted Solvent-Free Arylation of Amino acids with Halogenobenzenes. Journal of Chemical Society of Nigeria, 43(3). Retrieved from https://journals.chemsociety.org.ng/index.php/jcsn/article/view/175

Issue

Vol. 43 No. 3 (2018)

Section

Articles

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Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution (CC-BY) 4.0 License that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal.