PHYTOCHEMICAL SCREENING OF ETHANOLIC EXTRACT OF HELIOTROPIUM INDICUM LEAF AND ITS HAEMOSTATIC EFFECT IN SPRAGUE DAWLEY RATS

Authors

  • O. O Olaleye
  • K. U. Nwaeze
  • A. T. Afolabi
  • D. A. Ota

Abstract

The study was carried out to investigate the phytochemical and haemostatic effect of ethanol extract of Heliotropium indicum leaf in Sprague Dawley rats using bleeding time, clotting time, plasma fibrinogen and prothrombin time as parameters. The extract was administered at doses of 100, 500, 1000 and 1500mg/kg by oral gavage and vitamin K was used as the standard at a dose of 0.1ml (intramuscularly) and there was a control group that received neither the extract nor vitamin K. The extract of Heliotropium indicum leaf had effect on bleeding time, clotting time, plasma fibrinogen and prothrombin time. Alkaloids, flavonoids, saponins and tannins were present. From the results obtained, it can be concluded that the leaves of Heliotropium indicum can be used as a haemostatic agent as a result of its phytochemicals. Keywords: Haemostatic effect, Heliotropium indicum, Ethanolic extract, Phytochemical.

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Published

2019-12-08

How to Cite

Olaleye, O. O., Nwaeze, K. U., Afolabi, A. T., & Ota, D. A. (2019). PHYTOCHEMICAL SCREENING OF ETHANOLIC EXTRACT OF HELIOTROPIUM INDICUM LEAF AND ITS HAEMOSTATIC EFFECT IN SPRAGUE DAWLEY RATS. Journal of Chemical Society of Nigeria, 44(7). Retrieved from https://journals.chemsociety.org.ng/index.php/jcsn/article/view/391

Issue

Vol. 44 No. 7 (2019): JCSN

Section

Articles

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Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution (CC-BY) 4.0 License that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal.