Synthesis, Characterization and In vitro Bioactivity of Chitosan- Hydroxyapatite Composite Doped with Magnesium

Authors

  • I. Abdullahi
  • I. Zainol

Abstract

This work reports the synthesis, characterization and in vitro response of a novel chitosan-hydroxyapatite composite doped with magnesium. Hydroxyapatite (HA), magnesium doped HA, chitosan-hydroxyapatite composite and the novel magnesium doped chitosan-hydroxyapatite composite were synthesised using co-precipitation method. The effects of magnesium and chitosan incorporation on the structural properties of the samples were studied by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and differential thermal analysis (DTA). Bioactivity studies of the samples in simulated body fluid (SBF)  was carried out. The incorporation of magnesium and chitosan into the lattice of the HA reduced the crystallinity and crystallite size of the HA. The chemical composition of the novel magnesium doped chitosan-HA composite was found to have resemblance to that of bone mineral. The novel material showed good bioactivity in SBF. Keywords: hydroxyapatite, chitosan, composite, bioactivity, antimicrobial

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Published

2019-12-09

How to Cite

Abdullahi, I., & Zainol, I. (2019). Synthesis, Characterization and In vitro Bioactivity of Chitosan- Hydroxyapatite Composite Doped with Magnesium. Journal of Chemical Society of Nigeria, 44(7). Retrieved from https://journals.chemsociety.org.ng/index.php/jcsn/article/view/413

Issue

Vol. 44 No. 7 (2019): JCSN

Section

Articles

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Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution (CC-BY) 4.0 License that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal.