PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF NIGERIAN KALANCHOE PINNATA (LAM.) STEM-BARK
AbstractKalanchoe pinnata also known as Bryophyllum pinnatum and commonly referred to as Life or Miracle plant is used in traditional medicine in some parts of Nigeria. The stem-bark of the plant was extracted with 70% ethanol and the crude extract evaluated for its phytochemical constituents as well as pharmacological activities. The phytochemical profile showed the presence of alkaloids, flavonoids, glycosides, phenolics, steroids/terpenes and tannins while the quantitative analysis gave the phenolics content to be 5.538 ± 0.005 mg gallic acid equivalent, flavonoid content as 0.242 ± 0.001 mg quercetin equivalent and tannin content as 0.019 ± 0.001 mg tannic acid equivalent per gram of extract. The scavenging activity on DPPH (1,1-diphenyl-2-picryl hydrazyl) radical showed that the plant exhibited higher antioxidant activity with IC50 value of 40.56 and 37.28 µg/ml for ascorbic acid and the extract respectively. The antimicrobial activity results showed that the extract inhibited the growth of micro-organisms such as Bacillus cereus, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and Aspergillus niger; while the extract was inactive against Salmonella typhi and Candida albicans. These results give scientific evidence for the use of the plant in folk medicine.
How to Cite
Kendeson, C. A. ., Kagoro, M. L., & Adelakun, E. A. . (2021). PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF NIGERIAN KALANCHOE PINNATA (LAM.) STEM-BARK . Journal of Chemical Society of Nigeria, 46(4). https://doi.org/10.46602/jcsn.v46i4.654