SYNTHESIS, CHARACTERIZATION AND COMPLEXATION OF Cr(III) ION USING CHLOROQUINE DIPHOSPHATE DRUG

Authors

  • I. E. Otuokere
  • L. O. Okpara
  • K. C. Amadi
  • N. Ikpo

Abstract

Chloroquine is a member of the drug class 4-aminoquinoline used for the prevention and treatment of malaria in areas where malaria is known to be sensitive to its effects. It works against the asexual form of malaria inside the red blood cell. Cr (III) complex of chloroquine was synthesized by reaction of chloroquine phosphate with chromium (III) chloride. The chromium complex was characterized based on UV, IR, Mass and 1H NMR Spectroscopy. The UV spectrum of the ligand showed intra charge transfer which were assigned to the chromophores present in the ligand, while that of the complex suggested intra ligand charge transfer (ILCT), ligand to metal charge transfer (LMCT), and d-d transition. The IR spectra of the complex showed the involvement of amine and imine group in coordination to the metals. This shows that chloroquine acted as a bidentate ligand. 1H NMR Spectra of the complex further showed the involvement of the amine group in coordination to the metal complex. The results showed that chloroquine has the ability to sequestrate Cr ion from solution. We recommend the use of chloroquine in heavy metal extraction and chelation therapy.Keywords: Chloroquine, spectra, coordination, chromium

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Published

2019-01-20

How to Cite

Otuokere, I. E., Okpara, L. O., Amadi, K. C., & Ikpo, N. (2019). SYNTHESIS, CHARACTERIZATION AND COMPLEXATION OF Cr(III) ION USING CHLOROQUINE DIPHOSPHATE DRUG. Journal of Chemical Society of Nigeria, 44(1). Retrieved from https://journals.chemsociety.org.ng/index.php/jcsn/article/view/254

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