SYNTHESIS, CHARACTERIZATION AND COMPLEXATION OF Cr(III) ION USING CHLOROQUINE DIPHOSPHATE DRUG
Abstract
Chloroquine is a member of the drug class 4-aminoquinoline used for the prevention and treatment of malaria in areas where malaria is known to be sensitive to its effects. It works against the asexual form of malaria inside the red blood cell. Cr (III) complex of chloroquine was synthesized by reaction of chloroquine phosphate with chromium (III) chloride. The chromium complex was characterized based on UV, IR, Mass and 1H NMR Spectroscopy. The UV spectrum of the ligand showed intra charge transfer which were assigned to the chromophores present in the ligand, while that of the complex suggested intra ligand charge transfer (ILCT), ligand to metal charge transfer (LMCT), and d-d transition. The IR spectra of the complex showed the involvement of amine and imine group in coordination to the metals. This shows that chloroquine acted as a bidentate ligand. 1H NMR Spectra of the complex further showed the involvement of the amine group in coordination to the metal complex. The results showed that chloroquine has the ability to sequestrate Cr ion from solution. We recommend the use of chloroquine in heavy metal extraction and chelation therapy.Keywords: Chloroquine, spectra, coordination, chromiumDownloads
Published
2019-01-20
How to Cite
Otuokere, I. E., Okpara, L. O., Amadi, K. C., & Ikpo, N. (2019). SYNTHESIS, CHARACTERIZATION AND COMPLEXATION OF Cr(III) ION USING CHLOROQUINE DIPHOSPHATE DRUG. Journal of Chemical Society of Nigeria, 44(1). Retrieved from https://journals.chemsociety.org.ng/index.php/jcsn/article/view/254
Issue
Section
Articles
License
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution (CC-BY) 4.0 License that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal.