SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF MIXED LIGAND COMPLEXES OF BENZYLIMINOTHIOSEMICARBAZIDE AND L-PHENYLALANINE WITH DIVALENT Fe, Co AND Ni

Authors

  • E. T. Omotade
  • A. P. Oviawe
  • E. E. Elemike

Abstract

Abstract  In this work, benzyliminothiosemicarbazide (L3) was synthesized by solvent-free approach, and its Fe(II), Co(II) and Ni(II) mixed ligand complexes with L-phenylalanine (Phe) as co-ligand (AH), were also synthesized. The resulting Schiff base and complexes were characterized by elemental analysis, thermal analysis, conductivity measurement, UV/Visible, Fourier Transform Infra-red FTIR spectroscopy, Mass spectrometry (MS), Nuclear Magnetic Resonance (1H-NMR and C-NMR) spectral studies. All the complexes were screened for their antimicrobial activity against bacteria viz. Escherichia coli, Pseudomonas aeroginosa, Staphylococcus aureus, Bacillus subtilis and fungi viz. Candida albicans and Aspergillus niger. The Schiff base behaved as bidentate ligand by coordinating through the imine N and amino N whereas the amino acid coordinated through the carboxylate O and the amino N. The complexes showed octahedral geometry and were found to be non-electrolytes on the basis of low molar conductance values. They were also less thermally stable than the Schiff base ligand. In comparison with the Schiff base ligand, co-ligand and standard drugs, the antimicrobial results showed that the complexes were more potent against the test bacteria and fungi.Keywords:   Phenylalanine, mixed ligand, thiosemicarbazone, complex, antimicrobial

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Published

2020-03-30

How to Cite

Omotade, E. T., Oviawe, A. P., & Elemike, E. E. (2020). SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF MIXED LIGAND COMPLEXES OF BENZYLIMINOTHIOSEMICARBAZIDE AND L-PHENYLALANINE WITH DIVALENT Fe, Co AND Ni. Journal of Chemical Society of Nigeria, 45(2). Retrieved from https://journals.chemsociety.org.ng/index.php/jcsn/article/view/443

Issue

Vol. 45 No. 2 (2020)

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Articles

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